Hydrocortisone aceponate

Hydrocortisone aceponate
Clinical data
Trade names	Cortavance, others
AHFS/Drugs.com	Monograph
Routes of; administration	Topical
Drug class	Corticosteroid
ATC code	D07AC16 (WHO) QD07AC16 (WHO);
Legal status
Legal status	EU: Rx-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	6-8 hours
Identifiers
	IUPAC name (11β)-21-(acetyloxy)-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate;
CAS Number	74050-20-7 ;
PubChem CID	68921;
DrugBank	DB14538 ;
ChemSpider	62148 ;
UNII	2340UP1L2G;
KEGG	D06876 ;
ChEBI	CHEBI:135746;
ChEMBL	ChEMBL2106309 ;
ECHA InfoCard	100.184.885
Chemical and physical data
Formula	C26H36O7
Molar mass	460.567 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)C;
	InChI InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1 ; Key:MFBMYAOAMQLLPK-FZNHGJLXSA-N ;
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Hydrocortisone aceponate is a veterinary corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).^[4] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.

^ Cite error: The named reference Easotic EPAR was invoked but never defined (see the help page).
^ Cite error: The named reference Cortavance EPAR was invoked but never defined (see the help page).
^ "Cortaderm EPAR". European Medicines Agency (EMA). 17 June 2022. Retrieved 9 February 2024.
^ Mukhopadhyay AK, Baghel V (2010). "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology and Leprology. 76 (5): 591. doi:10.4103/0378-6323.69093. PMID 20827017.