| US12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Herpes_US12 | ||||||||
| Pfam | PF05363 | ||||||||
| InterPro | IPR008026 | ||||||||
| CATH | 5U1D | ||||||||
| SCOP2 | 1qlo / SCOPe / SUPFAM | ||||||||
| |||||||||
Infected cell protein 47 also ICP-47 or ICP47 is a protein encoded by the viruses such as Herpes simplex virus and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response by interfering with an infected cell's ability to show viral epitopes to T cells.[1] Its secondary structure shows three helices.
- ^ Goldsmith K, Chen W, Johnson DC, Hendricks RL (February 1998). "Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response". The Journal of Experimental Medicine. 187 (3): 341–8. CiteSeerX 10.1.1.282.6406. doi:10.1084/jem.187.3.341. PMC 2212130. PMID 9449714.