Look up irk in Wiktionary, the free dictionary.
Irk or IRK may refer to:
- River Irk, a lake in northwest England
- Irk Valley, location of the Irk Valley Junction rail crash
- IATA airport code of Kirksville Regional Airport
- Inward-rectifier potassium ion channel, a class of protein
- ISO 639-3 code of the Iraqw language, a Cushitic language spoken in Tanzania
- Irk, the fictional homeworld of main character Zim in the animated TV series Invader Zim
- Islamic Republic of Kamistan, a fictional country in season 8 of the TV series 24
- Institutional Recovery Key, a special kind of password in FileVault