Isoniazid

Isoniazid
Clinical data
Trade names	Hydra, Hyzyd, Isovit, others
Other names	isonicotinic acid hydrazide, isonicotinyl hydrazine, INH, INAH, INHA
AHFS/Drugs.com	Monograph
MedlinePlus	a682401
License data	US DailyMed: Isoniazid;
Pregnancy; category	AU: A; ;
Routes of; administration	By mouth, intramuscular, intravenous
ATC code	J04AC01 (WHO) J04AC51 (WHO) J04AM01 (WHO) J04AM02 (WHO) J04AM03 (WHO) J04AM04 (WHO) J04AM05 (WHO) J04AM06 (WHO) J04AM07 (WHO) J04AM08 (WHO);
Legal status
Legal status	CA: ℞-only; US: WARNINGRx-only;
Pharmacokinetic data
Protein binding	Very low (0–10%)
Metabolism	liver; CYP450: 2C19, 3A4 inhibitor
Elimination half-life	0.5–1.6h (fast acetylators), 2-5h (slow acetylators)
Excretion	urine (primarily), feces
Identifiers
	IUPAC name Pyridine-4-carbohydrazide;
CAS Number	54-85-3 ;
PubChem CID	3767;
DrugBank	DB00951 ;
ChemSpider	3635 ;
UNII	V83O1VOZ8L;
KEGG	D00346 ; C07054 ;
ChEBI	CHEBI:6030 ;
ChEMBL	ChEMBL64 ;
NIAID ChemDB	007657;
CompTox Dashboard (EPA)	DTXSID8020755 ;
ECHA InfoCard	100.000.195
Chemical and physical data
Formula	C6H7N3O
Molar mass	137.142 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CN=CC=C1C(=O)NN;
	InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10) ; Key:QRXWMOHMRWLFEY-UHFFFAOYSA-N ;
	(verify)

Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis.^[4] For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol.^[5] For latent tuberculosis, it is often used alone.^[4] It may also be used for atypical types of mycobacteria, such as M. avium, M. kansasii, and M. xenopi.^[4] It is usually taken by mouth, but may be used by injection into muscle.^[4]

^ "Isoniazid (Nydrazid) Use During Pregnancy". Drugs.com. 7 October 2019. Retrieved 24 January 2020.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
^ ^a ^b ^c ^d "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 136. hdl:10665/44053. ISBN 9789241547659.