John McLoughlin (1784–1857) was a Canadian fur trader and Oregon pioneer.
John McLoughlin may also refer to:
- John McLoughlin (Proctor), a 1953 bronze sculpture of John McLoughlin by Alexander Phimister Proctor
- John McLoughlin (police officer) (born c. 1953), 9/11 attacks survivor
- John McLoughlin Jr. (1812–1842), Metis Chief Trader employed by the Hudson's Bay Company
- John McLaughlin (performance artist) (1956–1990), New York City performance artist, singer, and parodist, known as John Sex