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Combination of | |
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Lamivudine | Nucleoside analogue reverse transcriptase inhibitor |
Zidovudine | Nucleoside analogue reverse transcriptase inhibitor |
Clinical data | |
Trade names | Combivir |
AHFS/Drugs.com | Professional Drug Facts |
MedlinePlus | a601066 |
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Pregnancy category |
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Routes of administration | By mouth |
ATC code | |
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PubChem CID | |
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CompTox Dashboard (EPA) | |
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Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS.[2] It contains two antiretroviral medications, lamivudine and zidovudine.[2] It is used together with other antiretrovirals.[2] It is taken by mouth twice a day.[2][3]
Common side effects include headache, feeling tired, nausea, diarrhea, and fever.[3] Severe side effects may include bone marrow suppression, muscle damage, worsening of hepatitis B if previously infected, high blood lactate and liver enlargement.[2][4] It may be part of a recommended treatment during pregnancy.[2] The medications are both of the nucleoside reverse transcriptase inhibitor (NRTI) class.[2] They work by blocking the action of the enzyme, reverse transcriptase, that the virus requires to reproduce.[3]
Lamivudine/zidovudine was approved for medical use in the United States in 1997, and in the European Union in 1998.[3][5] It is on the World Health Organization's List of Essential Medicines.[6] It is available as a generic medication.[4]
Combivir EPAR
was invoked but never defined (see the help page).