The Lancaster and Carlisle Railway was a main line railway opened between those cities in 1846. With its Scottish counterpart, the Caledonian Railway, the Company launched the first continuous railway connection between the English railway network and the emerging network in central Scotland. The selection of its route was controversial, and strong arguments were put forward in favour of alternatives, in some cases avoiding the steep gradients, or connecting more population centres. Generating financial support for such a long railway was a challenge, and induced the engineer Joseph Locke to make a last-minute change to the route: in the interests of economy and speed of construction, he eliminated a summit tunnel at the expense of steeper gradients.
The sparseness of the population discouraged the addition of branch lines, with a small number of exceptions, although several east-west secondary routes made independent connection to the route. Establishing a joint station at Carlisle with the three other railway companies terminating there, seemed obviously appropriate, but proved hugely difficult, and the Lancaster and Carlisle Railway funded the main station practically single-handedly, in the face of outright obstruction.
The line was electrified in 1974 and at the present day is a key part of the West Coast Main Line, carrying long-distance passenger and freight trains.