The lipid hypothesis (also known as the cholesterol hypothesis) is a medical theory postulating a link between blood cholesterol levels and the occurrence of cardiovascular disease. A summary from 1976 described it as: "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary heart disease".[1] It states, more concisely, that "decreasing blood cholesterol [...] significantly reduces coronary heart disease".[2]
As of 2023, there is international clinical acceptance of the lipid hypothesis.[3][4][5][6]
- ^ Ahrens EH Jr (July 1976). "The management of hyperlipidemia: whether, rather than how". Ann Intern Med. 85 (1): 87–93. doi:10.7326/0003-4819-85-1-87. PMID 779574.
- ^ Steinberg D (2006). "An interpretive history of the cholesterol controversy, part IV: The 1984 coronary primary prevention trial ends it - almost". J Lipid Res. 47 (1): 1–14. doi:10.1194/jlr.R500014-JLR200. PMID 16227628.
- ^ Cite error: The named reference
Europeanwas invoked but never defined (see the help page). - ^ Linton MF, Yancey PG, Davies SS, et al. (3 January 2019). "The Role of Lipids and Lipoproteins in Atherosclerosis". Endotext. PMID 26844337.
- ^ Duarte Lau F, Giugliano RP (July 2022). "Lipoprotein(a) and its Significance in Cardiovascular Disease: A Review". JAMA Cardiology. 7 (7): 760–769. doi:10.1001/jamacardio.2022.0987. PMID 35583875.
- ^ "World Heart Report 2023: Confronting the World's Number One Killer" (PDF). World Heart Federation. 2023. Retrieved 22 January 2024.