Losey is a surname. Notable people with the surname include:
- Brian L. Losey, Rear Admiral, U.S. Navy; Commander, Combined Joint Task Force - Horn of Africa
- Frank H. Losey (1872–1931), musician, composer, and arranger of band and orchestra music
- Greg Losey (1950–2002), American pentathlete
- Joseph Losey (1909–1984), American theater and film director
- Gavrik Losey (born 1938), son of Joseph, film producer and production manager
- Luke Losey (born 1968), son of Gavrik, film director, lighting designer and photographer
- Marek Losey (born 1971), son of Gavrik, British-American film director and the third generation of film maker in the Losey family
- Gavrik Losey (born 1938), son of Joseph, film producer and production manager
- Robert M. Losey (1908–1940), aeronautical meteorologist, considered first U.S. military casualty in World War II
- Michael R. Losey (1938 -), President of MikeLosey.com; Retired President & CEO of the Society for Human Resource Management (SHRM), and author.