MYB (gene)

MYB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH
Identifiers
Aliases	MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
External IDs	OMIM: 189990; MGI: 97249; HomoloGene: 31311; GeneCards: MYB; OMA:MYB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 135,181,308 bp[1] End 135,219,173 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A3|10 9.75 cM Start 21,000,834 bp[2] End 21,036,883 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon bronchial epithelial cell trabecular bone bone marrow thymus rectum buccal mucosa cell bone marrow cells mucosa of transverse colon right uterine tube Top expressed in thymus tibiofemoral joint left colon fetal liver hematopoietic progenitor cell crypt of lieberkuhn of small intestine Paneth cell hair follicle femur body of femur granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear matrix nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated chromatin remodeling negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of histone H3-K4 methylation transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of histone H3-K9 methylation positive regulation of T-helper cell differentiation transcription by RNA polymerase II mitotic cell cycle response to hypoxia positive regulation of collagen biosynthetic process positive regulation of neuron apoptotic process positive regulation of smooth muscle cell proliferation positive regulation of glial cell proliferation cellular response to hydrogen peroxide cellular response to retinoic acid positive regulation of transforming growth factor beta production positive regulation of neuron death positive regulation of hepatic stellate cell proliferation positive regulation of hepatic stellate cell activation positive regulation of testosterone secretion regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4602 17863 Ensembl ENSG00000118513 ENSMUSG00000019982 UniProt P10242 Q708E1 P06876 RefSeq (mRNA) NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375 NM_001198914 NM_010848 NM_033597 RefSeq (protein) NP_001123644 NP_001123645 NP_001155128 NP_001155129 NP_001155130 NP_001155131 NP_001155132 NP_005366 NP_001185843 NP_034978 Location (UCSC) Chr 6: 135.18 – 135.22 Mb Chr 10: 21 – 21.04 Mb PubMed search [3] [4]
Wikidata
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Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper.^[5][6] Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.