Male infertility crisis

The male infertility crisis is an increase in male infertility since the mid-1970s.[1] The issue attracted media attention after a 2017 meta-analysis found that sperm counts had declined by 52.4 percent between 1973 and 2011.[2][3] The decline is particularly prevalent in Western countries such as New Zealand, Australia, Europe, and North America.[4] A 2022 meta-analysis reported that this decline extends to non-Western countries, namely those in Asia, Africa, Central America, and South America.[5] This meta-analysis also suggests that the decline in sperm counts may be accelerating.[5]

This decline in male fertility is the subject of research and debate. Proposed explanations include lifestyle factors, such as changes in diet and physical activity levels, and increased exposure to endocrine disrupting chemicals, such as those found in plastics and pesticides.[6][7] Some scientists[8][9] have questioned the extent of the crisis; the scientific community, however, generally acknowledges increasing male infertility as a men's-health issue.[10]

  1. ^ McKie, Robin (2017-07-29). "The infertility crisis is beyond doubt. Now scientists must find the cause". The Guardian. Retrieved 2018-10-10.
  2. ^ Levine, Hagai; Jørgensen, Niels; Martino-Andrade, Anderson; Mendiola, Jaime; Weksler-Derri, Dan; Mindlis, Irina; Pinotti, Rachel; Swan, Shanna H (2017-07-25). "Temporal trends in sperm count: a systematic review and meta-regression analysis". Human Reproduction Update. 23 (6): 646–659. doi:10.1093/humupd/dmx022. ISSN 1355-4786. PMC 6455044. PMID 28981654.
  3. ^ Davis, Nicola (2017-07-25). "Sperm counts among western men have halved in last 40 years – study". The Guardian. Retrieved 2018-10-10.
  4. ^ Johnston, Ian (25 July 2017). "Western men's sperm counts plunge 60% in 40 years due to 'modern life'". The Independent. Retrieved 2018-10-10.
  5. ^ a b Levine, Hagai; Jørgensen, Niels; Martino-Andrade, Anderson; Mendiola, Jaime; Weksler-Derri, Dan; Jolles, Maya; Pinotti, Rachel; Swan, Shanna H. (2022-11-15). "Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries". Human Reproduction Update. 29 (2): 157–176. doi:10.1093/humupd/dmac035. ISSN 1460-2369. PMID 36377604.
  6. ^ Skakkebæk, Niels E.; Lindahl-Jacobsen, Rune; Levine, Hagai; Andersson, Anna-Maria; Jørgensen, Niels; Main, Katharina M.; Lidegaard, Øjvind; Priskorn, Lærke; Holmboe, Stine A.; Bräuner, Elvira V.; Almstrup, Kristian; Franca, Luiz R.; Znaor, Ariana; Kortenkamp, Andreas; Hart, Roger J. (March 2022). "Environmental factors in declining human fertility". Nature Reviews. Endocrinology. 18 (3): 139–157. doi:10.1038/s41574-021-00598-8. ISSN 1759-5037. PMID 34912078.
  7. ^ J, Whittaker (2023-02-02). "Dietary trends and the decline in male reproductive health". Hormones. 22 (2): 165–197. doi:10.1007/s42000-023-00431-z. ISSN 2520-8721. PMID 36725796.
  8. ^ Boulicault, Marion; Perret, Meg; Galka, Jonathan; Borsa, Alex; Gompers, Annika; Reiches, Meredith; Richardson, Sarah (2021-05-10). "The future of sperm: a biovariability framework for understanding global sperm count trends". Human Fertility. 25 (5): 888–902. doi:10.1080/14647273.2021.1917778. ISSN 1464-7273. PMID 33969777. S2CID 234344423.
  9. ^ "Global decline in male fertility linked to common pesticides". NBC News. 2023-11-15. Retrieved 2024-01-05.
  10. ^ De Jonge, C.; Barratt, C.L. R. (2019). "The present crisis in male reproductive health: an urgent need for a political, social, and research roadmap". Andrology. 7 (6): 762–768. doi:10.1111/andr.12673. ISSN 2047-2919. PMID 31241256.

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