Maria Manuela | |
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Princess of Portugal, Princess of Asturias | |
![]() Portrait by Antonis Mor | |
Duchess consort of Milan | |
Tenure | 12 November 1543 – 12 July 1545 |
Born | 15 October 1527 Coimbra |
Died | 12 July 1545 Valladolid | (aged 17)
Burial | |
Spouse | |
Issue | Carlos, Prince of Asturias |
House | Aviz |
Father | John III of Portugal |
Mother | Catherine of Austria |
Dona Maria Manuela (15 October 1527 – 12 July 1545[1]) was the eldest daughter and second child of King John III of Portugal and his wife Catherine of Austria.[2] She was Princess of Asturias and Duchess of Milan as the first wife of the future Philip II of Spain, and Princess of Portugal as heir presumptive to the Portuguese throne between 1527 and 1535.