Metalloprotein

The structure of hemoglobin. The heme cofactor, containing the metal iron, shown in green.

Metalloprotein is a generic term for a protein that contains a metal ion cofactor.[1][2] A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains[3] although there may be up to 3000 human zinc metalloproteins.[4]

  1. ^ Banci L (2013). "Metallomics and the Cell: Some Definitions and General Comments". In Sigel A, Sigel H, Sigel RK (eds.). Metallomics and the Cell. Metal Ions in Life Sciences. Vol. 12. Springer. pp. 1–13. doi:10.1007/978-94-007-5561-1_1. ISBN 978-94-007-5561-1. PMID 23595668.
  2. ^ Shriver DF, Atkins PW (1999). "Charper 19, Bioinorganic chemistry". Inorganic chemistry (3rd ed.). Oxford University Press. ISBN 978-0-19-850330-9.
  3. ^ Human reference proteome in Uniprot, accessed 12 Jan 2018
  4. ^ Andreini C, Banci L, Bertini I, Rosato A (November 2006). "Zinc through the three domains of life". Journal of Proteome Research. 5 (11): 3173–8. doi:10.1021/pr0603699. PMID 17081069.

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