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| methylglyoxal synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.3 | ||||||||
| CAS no. | 37279-01-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme methylglyoxal synthase (EC 4.2.3.3) catalyzes the chemical reaction
Attempts to observe reversibility of this reaction have been unsuccessful.[3]
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is glycerone-phosphate phosphate-lyase (methylglyoxal-forming). Other names in common use include methylglyoxal synthetase, and glycerone-phosphate phospho-lyase. This enzyme participates in pyruvate metabolism and is constitutively expressed.[3]
- ^ Commonly known as dihydroxyacetone phosphate
- ^ Commonly known as methylglyoxal
- ^ a b Hopper DJ, Cooper RA (March 1971). "The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis?". FEBS Letters. 13 (4): 213–216. doi:10.1016/0014-5793(71)80538-0. PMID 11945670. S2CID 7075947.