Minute virus of mice

Minute virus of mice
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Quintoviricetes
Order: Piccovirales
Family: Parvoviridae
Genus: Protoparvovirus
Species:
Virus:
Minute virus of mice

Minute virus of mice (MVM) is the exemplar virus of the species Rodent protoparvovirus 1, in the genus Protoparvovirus[1] of the Parvoviridae family of viruses.[2] MVM exists in multiple variant forms including MVMp, which is the prototype strain that infects cells of fibroblast origin, while MVMi, the immunosuppressive strain, infects T lymphocytes.[3] MVM is a common infection in laboratory mice due to its highly contagious nature.[4] The virus can be shed from infected mice via feces and urine, but also via fomites and nasal secretions.[4] Typically there are no clinical signs of infection in adult mice, however, experimental infection can cause multiple organ damage during fetal development or shortly after birth.[4]

  1. ^ "ICTV 10th Report (2018)Protoparvovirus".[dead link]
  2. ^ "ICTV 10th Report (2018)Parvoviridae".
  3. ^ Brownstein, David G.; Smith, Abigail L.; Johnson, Elizabeth A.; Pintel, David J.; Naeger, Lisa Kay; Tattersall, Peter (1992). "The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2". Journal of Virology. 66 (5): 3118–24. doi:10.1128/JVI.66.5.3118-3124.1992. PMC 241074. PMID 1373202.
  4. ^ a b c Baker, David G. (1998). "Natural pathogens of laboratory mice, rats, and rabbits and their effects on research". Clinical Microbiology Reviews. 11 (2): 231–66. doi:10.1128/CMR.11.2.231. PMC 106832. PMID 9564563.

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