Mississippi Delta may refer to:
- Mississippi Alluvial Plain, the entire alluvial plain of the Mississippi River, from the river mouth to southern Illinois
- Mississippi embayment, the upper two-thirds of the Mississippi Alluvial Plain, between central Louisiana and southern Illinois
- Mississippi Delta, a distinct cultural area in northwest Mississippi state; part of the Mississippi embayment
- Mississippi River Delta, the confluence of the Mississippi River with the Gulf of Mexico in Louisiana
- Mississippi Delta AVA [not outlined on the inset map], an American Viticultural Area including portions of Louisiana, Mississippi, and Tennessee
- "Mississippi Delta" (song), a 1967 song by Bobbie Gentry