Missouri Route 64

Route 64
Route information
Maintained by MoDOT
Length	51.290 mi[1] (82.543 km)
Existed	1922–present
Major junctions
West end	Route 254 near Pomme de Terre Lake
Major intersections	US 65 in Louisburg Route 73 at Pumpkin Center
East end	Route 5 in Lebanon
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← I-64 → US 65

Route 64 is a highway in central Missouri with endpoints of Route 254 south of Hermitage and Route 5 in Lebanon.

Route 64 is one of the original 1922 state highways and originally ran between Preston and Collins. It would eventually be moved further to the south with its older alignment becoming U.S. Route 54. It would also be extended east. It is also only one of three Missouri state highways bearing the same number as an Interstate highway in Missouri.