Back أكسيداز أحادي الأمين A Arabic MAOA Welsh Warrior Gene German مونوآمین اکسیداز A Persian Monoamino oxidase A Galician Monoamin-oxidáz A Hungarian モノアミン酸化酵素A Japanese Monoamin oksidaz A Turkish Моноаміноксидаза A Ukrainian
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| Aliases | MAOA, MAO-A, monoamine oxidase A, BRNRS | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 309850; MGI: 96915; HomoloGene: 203; GeneCards: MAOA; OMA:MAOA - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene.[5][6] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000189221 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025037 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hotamisligil GS, Breakefield XO (August 1991). "Human monoamine oxidase A gene determines levels of enzyme activity". American Journal of Human Genetics. 49 (2): 383–92. PMC 1683299. PMID 1678250.
- ^ Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC (May 1991). "Human monoamine oxidase A and B genes exhibit identical exon-intron organization". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3637–41. Bibcode:1991PNAS...88.3637G. doi:10.1073/pnas.88.9.3637. PMC 51507. PMID 2023912.
- ^ "Entrez Gene: MAOA monoamine oxidase A".