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Murine polyomavirus

Mus musculus polyomavirus 1
A rendering of an icosahedral viral capsid comprising 72 pentamers of VP1, colored such that areas of the surface closer to the interior center appear blue and areas further away appear red.
The capsid protein VP1 assembled into an icosahedral capsid structure comprising 72 pentamers, colored by distance from the interior center. From PDB: 1SIE​.[1]
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genus: Alphapolyomavirus
Species:
Mus musculus polyomavirus 1

Murine polyomavirus (also known as mouse polyomavirus, Polyomavirus muris, or Mus musculus polyomavirus 1, and in older literature as SE polyoma or parotid tumor virus; abbreviated MPyV) is an unenveloped double-stranded DNA virus of the polyomavirus family. The first member of the family discovered, it was originally identified by accident in the 1950s.[2][3] A component of mouse leukemia extract capable of causing tumors, particularly in the parotid gland, in newborn mice was reported by Ludwik Gross in 1953[4] and identified as a virus by Sarah Stewart and Bernice Eddy at the National Cancer Institute, after whom it was once called "SE polyoma".[5][6][7] Stewart and Eddy would go on to study related polyomaviruses such as SV40 that infect primates, including humans. These discoveries were widely reported at the time and formed the early stages of understanding of oncoviruses.[8][9]

  1. ^ Stehle, T; Harrison, SC (15 February 1996). "Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments". Structure. 4 (2): 183–94. doi:10.1016/s0969-2126(96)00021-4. PMID 8805524.
  2. ^ Gross, L (November 1976). "The fortuitous isolation and identification of the polyoma virus". Cancer Research. 36 (11 Pt 1): 4195–6. PMID 184928.
  3. ^ Ramqvist, T; Dalianis, T (August 2009). "Murine polyomavirus tumour specific transplantation antigens and viral persistence in relation to the immune response, and tumour development". Seminars in Cancer Biology. 19 (4): 236–43. doi:10.1016/j.semcancer.2009.02.001. PMID 19505651.
  4. ^ Gross, L. (1953). "A Filterable Agent, Recovered from Ak Leukemic Extracts, Causing Salivary Gland Carcinomas in C3H Mice". Experimental Biology and Medicine. 83 (2): 414–21. doi:10.3181/00379727-83-20376. PMID 13064287. S2CID 34223353.
  5. ^ STEWART, SE; EDDY, BE; BORGESE, N (June 1958). "Neoplasms in mice inoculated with a tumor agent carried in tissue culture". Journal of the National Cancer Institute. 20 (6): 1223–43. doi:10.1093/jnci/20.6.1223. PMID 13549981.
  6. ^ Eddy, Bernice E.; Stewart, Sarah E. (November 1959). "Characteristics of the SE Polyoma Virus". American Journal of Public Health and the Nation's Health. 49 (11): 1486–1492. doi:10.2105/AJPH.49.11.1486. PMC 1373056. PMID 13819251.
  7. ^ Percy, Dean H.; Barthold, Stephen W. (2013). "Polyoma Virus Infection". Pathology of Laboratory Rodents and Rabbits (3rd ed.). John Wiley & Sons. ISBN 978-1118704639.
  8. ^ Harris, R.J.C. (7 July 1960). "Cancer-inducing Viruses". New Scientist. 8 (190): 21–3.
  9. ^ Morgan, Gregory J. (December 2014). "Ludwik Gross, Sarah Stewart, and the 1950s discoveries of Gross murine leukemia virus and polyoma virus". Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences. 48: 200–209. doi:10.1016/j.shpsc.2014.07.013. PMID 25223721.
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