NUMB (gene)

NUMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJ1
Identifiers
Aliases	NUMB, C14orf41, S171, c14_5527, endocytic adaptor protein, NUMB endocytic adaptor protein
External IDs	OMIM: 603728; MGI: 107423; HomoloGene: 2775; GeneCards: NUMB; OMA:NUMB - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.2-q24.3 Start 73,275,107 bp[1] End 73,458,617 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 83,840,808 bp[2] End 83,968,708 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte epithelium of colon right lung blood gallbladder right uterine tube stromal cell of endometrium rectum oocyte sural nerve Top expressed in medullary collecting duct vestibular membrane of cochlear duct conjunctival fornix granulocyte Epithelium of choroid plexus hair follicle right lung saccule left lung right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding protein binding alpha-catenin binding cadherin binding Cellular component cytoplasm membrane focal adhesion plasma membrane apical part of cell basolateral plasma membrane early endosome extrinsic component of plasma membrane nucleus clathrin-coated vesicle cytoplasmic vesicle glutamatergic synapse Biological process neuroblast division in subventricular zone lateral ventricle development axonogenesis positive regulation of cell migration nervous system development multicellular organism development positive regulation of neurogenesis negative regulation of protein localization to plasma membrane neuroblast proliferation lung epithelial cell differentiation positive regulation of polarized epithelial cell differentiation forebrain development adherens junction organization negative regulation of Notch signaling pathway regulation of postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8650 18222 Ensembl ENSG00000133961 ENSMUSG00000021224 UniProt P49757 Q9QZS3 RefSeq (mRNA) NM_001005743 NM_001005744 NM_001005745 NM_003744 NM_001320114 NM_001136075 NM_001272055 NM_001272056 NM_010949 RefSeq (protein) NP_001005743 NP_001005744 NP_001005745 NP_001307043 NP_003735 NP_001129547 NP_001258984 NP_001258985 NP_035079 Location (UCSC) Chr 14: 73.28 – 73.46 Mb Chr 12: 83.84 – 83.97 Mb PubMed search [3] [4]
Wikidata
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Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.^[5]

The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved.^[6] Numb has been extensively studied in both invertebrates and mammals, though its function is best understood in Drosophila. Numb plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. During neurogenesis, Numb localizes to one side of the mother cell such that it is distributed selectively to one daughter cell. This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell.