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Other names | CI-628; CN-5518; CN-55945 |
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Chemical and physical data | |
Formula | C27H28N2O4 |
Molar mass | 444.531 g·mol−1 |
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Nitromifene (INN ; also as the citrate salt nitromifene citrate (USAN ), developmental code names CI-628, CN-5518, CN-55945) is a nonsteroidal selective estrogen receptor modulator (SERM) related to triphenylethylenes like tamoxifen that was never marketed.[1] It is a mixture of (E)- and (Z)-isomers that possess similar antiestrogenic activity.[2] The drug was described in 1966.[1] Along with tamoxifen, nafoxidine, and clomifene, it was one of the earliest SERMs.[3]
Nitromifene has been found to dissociate from the estrogen receptor 250-fold faster than estradiol.[4] This may be involved in its antagonistic activity at the estrogen receptor.[4]