Back نورتريبتيلين Arabic نورتریپتیلین AZB Nortriptylin Welsh Nortriptylin German Nortriptilina Spanish Nortriptüliin Estonian نورتریپتیلین Persian Nortriptyliini Finnish Nortriptyline French נורטריפטילין HE
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| Clinical data | |
|---|---|
| Trade names | Aventyl, others |
| Other names | Desitriptyline; ELF-101; E.L.F. 101; N-7048 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682620 |
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| Routes of administration | By mouth |
| Drug class | Tricyclic antidepressant (TCA) |
| ATC code | |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | 32–79%[4] |
| Protein binding | 92%[4] |
| Metabolism | Liver |
| Metabolites | 10-E-Hydroxynortriptyline |
| Elimination half-life | 18–44 hours (mean 30 hours)[4] |
| Excretion | Urine: 40%[4] Feces: minor[4] |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.717 |
| Chemical and physical data | |
| Formula | C19H21N |
| Molar mass | 263.384 g·mol−1 |
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Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety.[5][6] As with many antidepressants, its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18–24 population initiating treatment.[6] Nortriptyline is a less preferred treatment for ADHD and stopping smoking.[6] It is taken by mouth.[6]
Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness.[6] Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues.[6] Nortriptyline may cause problems if taken during pregnancy.[6] Use during breastfeeding appears to be relatively safe.[5] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.[6][a]
Nortriptyline was approved for medical use in the United States in 1964.[6] It is available as a generic medication.[5] In 2021, it was the 139th most commonly prescribed medication in the United States, with more than 4 million prescriptions.[7][8]
- ^ "Nortriptyline Use During Pregnancy". Drugs.com. 22 June 2020. Retrieved 10 October 2020.
- ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
- ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
- ^ a b c d e Lemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 374. ISBN 9780857113382.
- ^ a b c d e f g h i "Nortriptyline Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 22 March 2019.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Nortriptyline - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
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