| Betacoronavirus viroporin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| Symbol | bCoV_viroporin | ||||||||
| Pfam | PF11289 | ||||||||
| InterPro | IPR024407 | ||||||||
| |||||||||
ORF3a (previously known as X1 or U274)[2] is a gene found in coronaviruses of the subgenus Sarbecovirus, including SARS-CoV[3][2] and SARS-CoV-2.[1][4] It encodes an accessory protein about 275 amino acid residues long, which is thought to function as a viroporin.[1] It is the largest accessory protein[2][4] and was the first of the SARS-CoV accessory proteins to be described.[3]
- ^ a b c Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, et al. (July 2021). "Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs". Nature Structural & Molecular Biology. 28 (7): 573–582. doi:10.1038/s41594-021-00619-0. PMC 8772433. PMID 34158638. S2CID 235609553.
- ^ a b c Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R (September 2014). "Accessory proteins of SARS-CoV and other coronaviruses". Antiviral Research. 109: 97–109. doi:10.1016/j.antiviral.2014.06.013. PMC 7113789. PMID 24995382.
- ^ a b McBride R, Fielding BC (November 2012). "The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis". Viruses. 4 (11): 2902–2923. doi:10.3390/v4112902. PMC 3509677. PMID 23202509.
- ^ a b Redondo N, Zaldívar-López S, Garrido JJ, Montoya M (7 July 2021). "SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns". Frontiers in Immunology. 12: 708264. doi:10.3389/fimmu.2021.708264. PMC 8293742. PMID 34305949.