Betacoronavirus NS7A protein | |||||||||
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![]() Structure of the SARS-coronavirus ORF7a accessory protein | |||||||||
Identifiers | |||||||||
Symbol | bCoV_NS7A | ||||||||
Pfam | PF08779 | ||||||||
InterPro | IPR014888 | ||||||||
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ORF7a (also known by several other names, including SARS coronavirus X4, SARS-X4, ORF7a, or U122)[1] is a gene found in coronaviruses of the Betacoronavirus genus. It expresses the Betacoronavirus NS7A protein, a type I transmembrane protein with an immunoglobulin-like protein domain. It was first discovered in SARS-CoV, the virus that causes severe acute respiratory syndrome (SARS).[2] The homolog in SARS-CoV-2, the virus that causes COVID-19, has about 85% sequence identity to the SARS-CoV protein.[3]