| Betacoronavirus NS7A protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the SARS-coronavirus ORF7a accessory protein | |||||||||
| Identifiers | |||||||||
| Symbol | bCoV_NS7A | ||||||||
| Pfam | PF08779 | ||||||||
| InterPro | IPR014888 | ||||||||
| |||||||||
ORF7a (also known by several other names, including SARS coronavirus X4, SARS-X4, ORF7a, or U122)[1] is a gene found in coronaviruses of the Betacoronavirus genus. It expresses the Betacoronavirus NS7A protein, a type I transmembrane protein with an immunoglobulin-like protein domain. It was first discovered in SARS-CoV, the virus that causes severe acute respiratory syndrome (SARS).[2] The homolog in SARS-CoV-2, the virus that causes COVID-19, has about 85% sequence identity to the SARS-CoV protein.[3]
- ^ Liu, DX; Fung, TS; Chong, KK; Shukla, A; Hilgenfeld, R (September 2014). "Accessory proteins of SARS-CoV and other coronaviruses". Antiviral Research. 109: 97–109. doi:10.1016/j.antiviral.2014.06.013. PMC 7113789. PMID 24995382.
- ^ Nelson CA, Pekosz A, Lee CA, Diamond MS, Fremont DH (2005). "Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein". Structure. 13 (1): 75–85. doi:10.1016/j.str.2004.10.010. PMC 7125549. PMID 15642263.
- ^ Redondo, Natalia; Zaldívar-López, Sara; Garrido, Juan J.; Montoya, Maria (7 July 2021). "SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns". Frontiers in Immunology. 12: 708264. doi:10.3389/fimmu.2021.708264. hdl:10261/249329. PMC 8293742. PMID 34305949.