| Betacoronavirus lipid binding protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The X-ray crystallography structure of the SARS-CoV ORF9b protein dimer, showing the lipid molecule in the central cavity (yellow). From PDB: 2CME.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | bCoV_lipid_BD | ||||||||
| Pfam | PF09399 | ||||||||
| InterPro | IPR018542 | ||||||||
| |||||||||
ORF9b (formerly sometimes called ORF13) is a gene that encodes a viral accessory protein in coronaviruses of the subgenus Sarbecovirus, including SARS-CoV and SARS-CoV-2. It is an overlapping gene whose open reading frame is entirely contained within the N gene, which encodes coronavirus nucleocapsid protein.[2][3][4] The encoded protein is 97 amino acid residues long in SARS-CoV[2][3] and 98 in SARS-CoV-2,[4] in both cases forming a protein dimer.
- ^ Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, et al. (July 2006). "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus". Structure. 14 (7): 1157–1165. doi:10.1016/j.str.2006.05.012. PMC 7126280. PMID 16843897.
- ^ a b Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R (September 2014). "Accessory proteins of SARS-CoV and other coronaviruses". Antiviral Research. 109: 97–109. doi:10.1016/j.antiviral.2014.06.013. PMC 7113789. PMID 24995382.
- ^ a b McBride R, Fielding BC (November 2012). "The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis". Viruses. 4 (11): 2902–2923. doi:10.3390/v4112902. PMC 3509677. PMID 23202509.
- ^ a b Redondo N, Zaldívar-López S, Garrido JJ, Montoya M (7 July 2021). "SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns". Frontiers in Immunology. 12: 708264. doi:10.3389/fimmu.2021.708264. PMC 8293742. PMID 34305949.