P53

TP53
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA
Identifiers
Aliases	TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
External IDs	OMIM: 191170; MGI: 98834; HomoloGene: 460; GeneCards: TP53; OMA:TP53 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,661,779 bp[1] End 7,687,538 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.83 cM Start 69,471,185 bp[2] End 69,482,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence tendon of biceps brachii monocyte stromal cell of endometrium skin of abdomen rectum granulocyte skin of leg smooth muscle tissue Top expressed in tail of embryo genital tubercle embryo ventricular zone embryo epiblast yolk sac lip blastocyst somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding DNA-binding transcription factor activity protein self-association core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein phosphatase binding ATP binding transcription factor binding metal ion binding protein phosphatase 2A binding enzyme binding zinc ion binding chromatin binding protease binding damaged DNA binding protein binding histone acetyltransferase binding copper ion binding protein kinase binding chaperone binding DNA-binding transcription activator activity, RNA polymerase II-specific receptor tyrosine kinase binding p53 binding identical protein binding protein heterodimerization activity ubiquitin protein ligase binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding TFIID-class transcription factor complex binding mRNA 3'-UTR binding histone deacetylase binding disordered domain specific binding promoter-specific chromatin binding histone deacetylase regulator activity protein homodimerization activity MDM2/MDM4 family protein binding Cellular component cytoplasm mitochondrion nucleus nuclear body transcription factor TFIID complex nuclear matrix replication fork nucleolus endoplasmic reticulum nucleoplasm mitochondrial matrix PML body cytosol intracellular anatomical structure transcription regulator complex protein-containing complex site of double-strand break Biological process positive regulation of histone deacetylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest rhythmic process replicative senescence negative regulation of telomerase activity oligodendrocyte apoptotic process cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process regulation of mitochondrial membrane permeability positive regulation of reactive oxygen species metabolic process cellular response to ionizing radiation positive regulation of thymocyte apoptotic process negative regulation of helicase activity cell cycle Ras protein signal transduction cell population proliferation cellular response to hypoxia negative regulation of cell population proliferation nucleotide-excision repair cellular response to glucose starvation regulation of transcription, DNA-templated response to antibiotic transcription, DNA-templated ER overload response positive regulation of transcription, DNA-templated negative regulation of cell growth intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of peptidyl-tyrosine phosphorylation viral process response to gamma radiation negative regulation of fibroblast proliferation positive regulation of intrinsic apoptotic signaling pathway cell differentiation determination of adult lifespan positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress cellular response to UV DNA damage response, signal transduction by p53 class mediator negative regulation of apoptotic process protein tetramerization oxidative stress-induced premature senescence positive regulation of release of cytochrome c from mitochondria circadian behavior negative regulation of transcription, DNA-templated protein localization intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of execution phase of apoptosis multicellular organism development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of gene expression mitotic G1 DNA damage checkpoint signaling positive regulation of protein oligomerization positive regulation of apoptotic process entrainment of circadian clock by photoperiod response to X-ray positive regulation of transcription by RNA polymerase II base-excision repair DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator regulation of cell cycle G2/M phase transition proteasome-mediated ubiquitin-dependent protein catabolic process regulation of signal transduction by p53 class mediator apoptotic process transcription by RNA polymerase II positive regulation of protein export from nucleus programmed cell death regulation of apoptotic process protein deubiquitination phosphatidylinositol-mediated signaling negative regulation of transcription by RNA polymerase II autophagy mRNA transcription cytokine-mediated signaling pathway positive regulation of RNA polymerase II transcription preinitiation complex assembly RNA polymerase II preinitiation complex assembly protein homotetramerization protein-containing complex assembly cellular response to gamma radiation signal transduction by p53 class mediator cellular response to actinomycin D positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of production of miRNAs involved in gene silencing by miRNA in utero embryonic development somitogenesis release of cytochrome c from mitochondria hematopoietic progenitor cell differentiation T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment response to ischemia double-strand break repair regulation of transcription by RNA polymerase II protein import into nucleus response to oxidative stress transforming growth factor beta receptor signaling pathway gastrulation negative regulation of neuroblast proliferation central nervous system development heart development circadian rhythm negative regulation of DNA replication rRNA transcription response to UV response to salt stress embryo development ending in birth or egg hatching negative regulation of gene expression positive regulation of cardiac muscle cell apoptotic process cerebellum development negative regulation of transforming growth factor beta receptor signaling pathway T cell differentiation in thymus regulation of tissue remodeling multicellular organism growth positive regulation of mitochondrial membrane permeability positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of cell population proliferation mitochondrial DNA repair regulation of DNA damage response, signal transduction by p53 class mediator regulation of neuron apoptotic process negative regulation of proteolysis negative regulation of mitotic cell cycle bone marrow development embryonic organ development protein stabilization chromosome organization neuron apoptotic process regulation of cell cycle hematopoietic stem cell differentiation interferon-gamma-mediated signaling pathway cardiac septum morphogenesis positive regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of programmed necrotic cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of thymocyte apoptotic process necroptosis cellular response to UV-C negative regulation of mitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia regulation of fibroblast apoptotic process negative regulation of reactive oxygen species metabolic process regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7157 22059 Ensembl ENSG00000141510 ENSMUSG00000059552 UniProt P04637 P02340 RefSeq (mRNA) NM_001276761 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760 NM_001127233 NM_011640 RefSeq (protein) NP_000537 NP_001119584 NP_001119585 NP_001119586 NP_001119587 NP_001119588 NP_001119589 NP_001119590 NP_001263624 NP_001263625 NP_001263626 NP_001263627 NP_001263628 NP_001263689 NP_001263690 NP_001120705 NP_035770 Location (UCSC) Chr 17: 7.66 – 7.69 Mb Chr 11: 69.47 – 69.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation.^[5] As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.^[6] Hence TP53^{[note 1]} is classified as a tumor suppressor gene.^{[7][8][9][10][11]}

The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.^[5] TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome.^[12] In addition to the full-length protein, the human TP53 gene encodes at least 12 protein isoforms.^[13]

Cite error: There are <ref group=note> tags on this page, but the references will not show without a {{reflist|group=note}} template (see the help page).