Panic Room is a 2002 American thriller film directed by David Fincher.
Panic Room may also refer to:
- Panic room or safe room, a fortified room in a residence or business
- Panic Room (band), a Welsh progressive rock band
- Panic Room (album) or the title song, by Paulmac, 2005
- "Panic Room" (song), a 2018 song by Au/Ra and CamelPhat
- "Panic Room", a song by Silent Planet from Everything Was Sound, 2016
- "Panic Room", a song by Theory of a Deadman from Savages, 2014