Panthera is a genus of big cats.
Panthera may also refer to:
- Pipistrel Panthera, a Slovenian light aircraft model
- Panthera Corporation, a conservation charity for big cats
- Black panther, any melanistic color variant of Panthera
- Panthera (or Pandera or Pantera), a soldier referred to in the Talmud as Jesus' real father:
- Tiberius Julius Abdes Pantera, a Roman soldier of the Cohors I Sagittariorum, speculated to be Panthera
- Panthera, a poem by Thomas Hardy
- Panthera AB, a Swedish wheelchair manufacturer
- Panthera Virus, Italian drag queen