Pee Dee is a region of South Carolina.
Pee Dee or Peedee may also refer to:
- Pedee people, also spelled Pee Dee and Peedee, a Native American people, now concentrated in South Carolina
- Pee Dee, Anson County, North Carolina, United States, a populated place
- Pee Dee, Montgomery County, North Carolina, an unincorporated community
- Pee Dee River, in North and South Carolina
- Peedee Formation, a geologic formation in North and South Carolina
- Nickname for the Cleveland Plain Dealer, the major daily newspaper of Cleveland, Ohio, United States
- PeeDee the Pirate, mascot of the East Carolina Pirates
- Peedee Fryman, a fictional character on Steven Universe