Phyllodes tumor

Phyllodes tumor
Micrograph of a phyllodes tumor (right of image) with the characteristic long clefts and myxoid cellular stroma. Normal breast and fibrocystic change are also seen (left of image). H&E stain.
Phullon means 'leaf' in Greek. It is appropriately named to describe the characteristic papillary projections seen on histology in phyllodes tumors.

Phyllodes tumors (from Greek: phullon), are a rare type of biphasic fibroepithelial mass that form from the periductal stromal and epithelial cells of the breast.[1] They account for less than 1% of all breast neoplasms.[2] They were previously termed cystosarcoma phyllodes, coined by Johannes Müller in 1838, before being renamed to phyllodes tumor by the World Health Organization in 2003.[3] Phullon, which means 'leaf' in Greek, describes the unique papillary projections characteristic of phyllodes tumors on histology.[1] Diagnosis is made via a core-needle biopsy and treatment is typically surgical resection with wide margins (>1 cm), due to their propensity to recur.[4]

  1. ^ a b Hasdemir S, Tolunay Ş, Özşen M, Gökgöz MŞ (January 2020). "Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases". European Journal of Breast Health. 16 (1): 32–38. doi:10.5152/ejbh.2019.4709. PMC 6939715. PMID 31912011.
  2. ^ Konstantakos AK, Graham DJ (September 2003). "Cystosarcoma phyllodes tumors in men". The American Surgeon. 69 (9): 808–811. doi:10.1177/000313480306900916. PMID 14509333. S2CID 26206134.
  3. ^ Zhou ZR, Wang CC, Yang ZZ, Yu XL, Guo XM (November 2016). "Phyllodes tumors of the breast: diagnosis, treatment and prognostic factors related to recurrence". Journal of Thoracic Disease. 8 (11): 3361–3368. doi:10.21037/jtd.2016.11.03. PMC 5179374. PMID 28066617.
  4. ^ Komenaka IK, El-Tamer M, Pile-Spellman E, Hibshoosh H (September 2003). "Core needle biopsy as a diagnostic tool to differentiate phyllodes tumor from fibroadenoma". Archives of Surgery. 138 (9): 987–990. doi:10.1001/archsurg.138.9.987. PMID 12963656.

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