 | This article needs more reliable medical references for verification or relies too heavily on primary sources. (October 2021) |  |
| Poor ovarian reserve | |
|---|---|
| Other names | Impaired ovarian reserve, premature ovarian aging, declining ovarian reserve |
| Specialty | Gynecology |
Poor ovarian reserve is a condition of low fertility characterized by 1): low numbers of remaining oocytes in the ovaries or 2) possibly impaired preantral oocyte development or recruitment. Recent research suggests that premature ovarian aging and premature ovarian failure (aka primary ovarian insufficiency) may represent a continuum of premature ovarian senescence.[1] It is usually accompanied by high FSH (follicle stimulating hormone) levels.
Quality of the eggs may also be impaired.[2][3] However, other studies show no association with elevated FSH levels and genetic quality of embryos after adjusting for age. The decline in quality was age related, not FSH related as the younger women with high day three FSH levels had higher live birth rates than the older women with high FSH. There was no significant difference in genetic embryo quality between same aged women regardless of FSH levels.[4][5] A 2008 study concluded that diminished reserve did not affect the quality of oocytes and any reduction in quality in diminished reserve women was age related.[6] One expert concluded: in young women with poor reserve when eggs are obtained they have near normal rates of implantation and pregnancy rates, but they are at high risk for IVF cancellation; if eggs are obtained, pregnancy rates are typically better than in older woman with normal reserve. However, if the FSH level is extremely elevated these conclusions are likely not applicable.[7]
- ^ Gleicher N, Weghofer A, Oktay K, Barad D (October 2009). "Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)?". Human Reproduction. 24 (10): 2395–2400. doi:10.1093/humrep/dep256. PMID 19617205.
- ^ Gardner DK, Weissman A, Howles CM, Shoham Z (2001). Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives. Taylor & Francis. p. 528. ISBN 978-1-85317-870-2.
- ^ Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Rosenwaks Z (April 1989). "Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome". Fertility and Sterility. 51 (4): 651–654. doi:10.1016/S0015-0282(16)60615-5. PMID 2494082.
- ^ Thum MY, Abdalla HI, Taylor D (August 2008). "Relationship between women's age and basal follicle-stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment". Fertility and Sterility. 90 (2): 315–321. doi:10.1016/j.fertnstert.2007.06.063. PMID 17953958.
- ^ Abdalla H, Thum MY (April 2004). "An elevated basal FSH reflects a quantitative rather than qualitative decline of the ovarian reserve". Human Reproduction. 19 (4): 893–898. doi:10.1093/humrep/deh141. PMID 15016786.
- ^ Rosen MP, Shen S, Huddleston HG, Fujimoto VY, Cedars MI (September 2008). "What is diminished ovarian reserve (DOR) – reduced quantity vs. reduced quality?". Fertil. Steril. 90 (Supplement): S258. doi:10.1016/j.fertnstert.2008.07.1283.
- ^ Toner JP (March 2003). "Age = egg quality, FSH level = egg quantity". Fertility and Sterility. 79 (3): 491. doi:10.1016/S0015-0282(02)04840-9. PMID 12620427.