Prostaglandin EP2 receptor

PTGER2
Identifiers
Aliases	PTGER2, EP2, Prostaglandin E2 receptor, prostaglandin E receptor 2
External IDs	OMIM: 176804; MGI: 97794; HomoloGene: 739; GeneCards: PTGER2; OMA:PTGER2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	52,328,598 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	45,241,277 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; cartilage tissue; ; blood; ; bone marrow; ; bone marrow cells; ; canal of the cervix; ; gastric mucosa; ; trabecular bone; ; appendix;
	Top expressed in
	granulocyte; ; left lung lobe; ; stroma of bone marrow; ; olfactory epithelium; ; renal corpuscle; ; right lung lobe; ; Paneth cell; ; cumulus cell; ; embryo; ; barrel cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; prostaglandin E receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure;
Biological process	response to progesterone; G protein-coupled receptor signaling pathway; response to lipopolysaccharide; regulation of cell population proliferation; signal transduction; cellular response to prostaglandin E stimulus; adenylate cyclase-activating G protein-coupled receptor signaling pathway; inflammatory response; positive regulation of cytosolic calcium ion concentration; positive regulation of gastric mucosal blood circulation;
	Sources:Amigo / QuickGO
Orthologs
	5732
	19217
	ENSG00000125384
	ENSMUSG00000037759
	P43116
	Q62053
	NM_000956
	NM_008964
	NP_000947
	NP_032990
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin E₂ receptor 2, also known as EP₂, is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP₁, EP₃, and EP₄, which bind with and mediate cellular responses to PGE₂ and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors).^[5] EP has been implicated in various physiological and pathological responses.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125384 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "PTGER2 prostaglandin e receptor 2 [Homo sapiens (human)] - Gene - NCBI".
^ Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125384 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037759 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "PTGER2 prostaglandin e receptor 2 [Homo sapiens (human)] - Gene - NCBI".

[pmid21752876-6] Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.

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Prostaglandin EP2 receptor

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