Prostaglandin EP3 receptor

PTGER3
Identifiers
Aliases	PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3, lnc003875
External IDs	OMIM: 176806; MGI: 97795; HomoloGene: 105703; GeneCards: PTGER3; OMA:PTGER3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 70,852,353 bp[1] End 71,047,816 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H4|3 81.32 cM Start 157,272,529 bp[2] End 157,351,525 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule human kidney body of uterus renal medulla Skeletal muscle tissue of rectus abdominis tail of epididymis myometrium vena cava Epithelium of choroid plexus adipose tissue Top expressed in tunica adventitia of aorta lumbar spinal ganglion right kidney barrel cortex brown adipose tissue white adipose tissue subcutaneous adipose tissue tunica media of zone of aorta seminal vesicula intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity prostaglandin receptor activity signal transducer activity prostaglandin E receptor activity protein binding Cellular component nuclear envelope membrane plasma membrane integral component of plasma membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway positive regulation of fever generation cell death signal transduction negative regulation of gastric acid secretion phospholipase C-activating G protein-coupled receptor signaling pathway intestine smooth muscle contraction inflammatory response adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5733 19218 Ensembl ENSG00000050628 ENSMUSG00000040016 UniProt P43115 P30557 RefSeq (mRNA) NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720 NM_011196 NM_001359745 RefSeq (protein) NP_001119516 NP_942007 NP_942008 NP_942009 NP_942010 NP_942011 NP_942012 n/a Location (UCSC) Chr 1: 70.85 – 71.05 Mb Chr 3: 157.27 – 157.35 Mb PubMed search [3] [4]
Wikidata
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Prostaglandin EP₃ receptor (EP₃, 53kDa), is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the human gene PTGER3;^[5] it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₄, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors).^[6] EP has been implicated in various physiological and pathological responses.^[7]