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The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions.[1][2][3][4][5]
- ^ Cite error: The named reference
Boureuxwas invoked but never defined (see the help page). - ^ Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo". BioEssays. 29 (4): 356–370. doi:10.1002/bies.20558. PMC 1971132. PMID 17373658.
- ^ Ridley, Anne J (2015). "Rho GTPase signalling in cell migration". Current Opinion in Cell Biology. 36: 103–112. doi:10.1016/j.ceb.2015.08.005. PMC 4728192. PMID 26363959.
- ^ Ridley, Anne Jacqueline (2016). "Anne Ridley: Networking with Rho GTPases". Trends in Cell Biology. 26 (7): 465–466. doi:10.1016/j.tcb.2016.04.005. ISSN 0962-8924. PMID 27166090. (subscription required)
- ^ Heasman, Sarah J.; Ridley, Anne J. (2008). "Mammalian Rho GTPases: new insights into their functions from in vivo studies". Nature Reviews Molecular Cell Biology. 9 (9): 690–701. doi:10.1038/nrm2476. PMID 18719708. (subscription required)
