Rhodopsin

RHO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRHO, CSNBAD1, OPN2, RP4, rhodopsin, Rhodopsin, visual purple
External IDsOMIM: 180380; MGI: 97914; HomoloGene: 68068; GeneCards: RHO; OMA:RHO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000539

NM_145383

RefSeq (protein)

NP_000530

NP_663358

Location (UCSC)Chr 3: 129.53 – 129.54 MbChr 6: 115.91 – 115.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene[5] and a G-protein-coupled receptor (GPCR). It is the opsin of the rod cells in the retina and a light-sensitive receptor protein that triggers visual phototransduction in rods. Rhodopsin mediates dim light vision and thus is extremely sensitive to light.[6] When rhodopsin is exposed to light, it immediately photobleaches. In humans, it is regenerated fully in about 30 minutes, after which the rods are more sensitive.[7] Defects in the rhodopsin gene cause eye diseases such as retinitis pigmentosa and congenital stationary night blindness.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163914Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030324Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "RHO rhodopsin [Homo sapiens (human)]". NCBI. Retrieved 16 November 2017.
  6. ^ Litmann BJ, Mitchell DC (1996). "Rhodopsin structure and function". In Lee AG (ed.). Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set). Biomembranes: A Multi-Volume Treatise. Vol. 2. Greenwich, Conn: JAI Press. pp. 1–32. doi:10.1016/S1874-5342(07)80004-3. ISBN 978-1-55938-659-3.
  7. ^ Stuart JA, Brige RR (1996). "Characterization of the primary photochemical events in bacteriorhodopsin and rhodopsin". In Lee AG (ed.). Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set). Biomembranes: A Multi-Volume Treatise. Vol. 2. Greenwich, Conn: JAI Press. pp. 33–140. doi:10.1016/S1874-5342(07)80005-5. ISBN 978-1-55938-659-3.

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