Saint Barbara was an early Christian saint and martyr.
Saint Barbara may also refer to:
- Saint Barbara (The Cloisters), sculpture statuette in limewood with paint
- Saint Barbara (van Eyck), paintings by Netherlandish artist Jan van Eyck
- Saint Barbara (Parmigianino), oil on panel painting by Parmigianino
- Saint Barbara with a Donor, canvas painting by Lattanzio Gambara