Samuel Chase may refer to:
- Samuel Chase (1741–1811), signer of Declaration of Independence and Justice of the United States Supreme Court
- Samuel Chase (New York politician) (1789–1838), U.S. Congressman from New York
- USS Samuel Chase, Arthur Middleton class attack transport manned by the United States Coast Guard during World War II
- SS Samuel Chase, a Liberty ship
- Samuel T. Chase, American tennis player