Serapion (possibly died 41 BC) was strategos of Cyprus and an admiral of the Ptolemaic navy during the reign of Cleopatra VII in 43 BC. Against the intention of the Egyptian queen, he supported in the Roman civil war Gaius Cassius Longinus, but had to take refuge in Tyre and was finally handed over to Cleopatra in 41 BC. Perhaps he is identical with that Serapion, who was instructed by Julius Caesar to negotiate in 48 BC with the Egyptian commander Achillas.