Sevoflurane

Sevoflurane
Clinical data
Trade names	Ultane, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: B2; ;
Routes of; administration	Inhalation
Drug class	Anesthetic
ATC code	N01AB08 (WHO) QN01AB08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Metabolism	Liver by CYP2E1
Metabolites	Hexafluoroisopropanol
Elimination half-life	15–23 hours
Excretion	Kidney
Identifiers
	IUPAC name 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane;
CAS Number	28523-86-6 ;
PubChem CID	5206;
IUPHAR/BPS	7296;
DrugBank	DB01236 ;
ChemSpider	5017 ;
UNII	38LVP0K73A;
KEGG	D00547 ;
ChEBI	CHEBI:9130 ;
ChEMBL	ChEMBL1200694 ;
CompTox Dashboard (EPA)	DTXSID8046614 ;
ECHA InfoCard	100.171.146
Chemical and physical data
Formula	C4H3F7O
Molar mass	200.056 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.53 g/cm3
Boiling point	58.5 °C (137.3 °F)
	SMILES FC(F)(F)C(OCF)C(F)(F)F;
	InChI InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2 ; Key:DFEYYRMXOJXZRJ-UHFFFAOYSA-N ;
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Sevoflurane, sold under the brand name Sevorane, among others, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia. After desflurane, it is the volatile anesthetic with the fastest onset.^[8] While its offset may be faster than agents other than desflurane in a few circumstances, its offset is more often similar to that of the much older agent isoflurane. While sevoflurane is only half as soluble as isoflurane in blood, the tissue blood partition coefficients of isoflurane and sevoflurane are quite similar. For example, in the muscle group: isoflurane 2.62 vs. sevoflurane 2.57. In the fat group: isoflurane 52 vs. sevoflurane 50. As a result, the longer the case, the more similar will be the emergence times for sevoflurane and isoflurane.^[9]^[10]^[11]

It is on the World Health Organization's List of Essential Medicines.^[12]

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ "Ultane- sevoflurane liquid". DailyMed. 18 August 2022. Retrieved 29 June 2024.
^ "Sojourn- sevoflurane liquid". DailyMed. 26 June 2024. Retrieved 29 June 2024.
^ "SevoFlo EPAR". European Medicines Agency. 14 August 2007. Retrieved 29 June 2024.
^ "SevoFlo PI". Union Register of medicinal products. 13 December 2002. Retrieved 29 June 2024.
^ "Sevohale (previously known as Sevocalm) EPAR". European Medicines Agency. 29 July 2016. Retrieved 29 June 2024.
^ "Sevohale PI". Union Register of medicinal products. 24 June 2016. Retrieved 29 June 2024.
^ Sakai EM, Connolly LA, Klauck JA (December 2005). "Inhalation anesthesiology and volatile liquid anesthetics: focus on isoflurane, desflurane, and sevoflurane". Pharmacotherapy. 25 (12): 1773–1788. doi:10.1592/phco.2005.25.12.1773. PMID 16305297. S2CID 40873242.
^ Maheshwari K, Ahuja S, Mascha EJ, Cummings KC, Chahar P, Elsharkawy H, et al. (February 2020). "Effect of Sevoflurane Versus Isoflurane on Emergence Time and Postanesthesia Care Unit Length of Stay: An Alternating Intervention Trial". Anesthesia and Analgesia. 130 (2): 360–366. doi:10.1213/ANE.0000000000004093. PMID 30882520.{{cite journal}}: CS1 maint: overridden setting (link)
^ Sloan MH, Conard PF, Karsunky PK, Gross JB (March 1996). "Sevoflurane versus isoflurane: induction and recovery characteristics with single-breath inhaled inductions of anesthesia". Anesthesia and Analgesia. 82 (3): 528–532. doi:10.1213/00000539-199603000-00018. PMID 8623956.
^ Smith I, Ding Y, White PF (February 1992). "Comparison of induction, maintenance, and recovery characteristics of sevoflurane-N2O and propofol-sevoflurane-N2O with propofol-isoflurane-N2O anesthesia". Anesthesia and Analgesia. 74 (2): 253–259. doi:10.1213/00000539-199202000-00015. PMID 1731547. S2CID 12345796.
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

[1] Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.

[2] "Ultane- sevoflurane liquid". DailyMed. 18 August 2022. Retrieved 29 June 2024.

[3] "Sojourn- sevoflurane liquid". DailyMed. 26 June 2024. Retrieved 29 June 2024.

[SevoFlo_EPAR-4] "SevoFlo EPAR". European Medicines Agency. 14 August 2007. Retrieved 29 June 2024.

[5] "SevoFlo PI". Union Register of medicinal products. 13 December 2002. Retrieved 29 June 2024.

[6] "Sevohale (previously known as Sevocalm) EPAR". European Medicines Agency. 29 July 2016. Retrieved 29 June 2024.

[7] "Sevohale PI". Union Register of medicinal products. 24 June 2016. Retrieved 29 June 2024.

[8] Sakai EM, Connolly LA, Klauck JA (December 2005). "Inhalation anesthesiology and volatile liquid anesthetics: focus on isoflurane, desflurane, and sevoflurane". Pharmacotherapy. 25 (12): 1773–1788. doi:10.1592/phco.2005.25.12.1773. PMID 16305297. S2CID 40873242.

[9] Maheshwari K, Ahuja S, Mascha EJ, Cummings KC, Chahar P, Elsharkawy H, et al. (February 2020). "Effect of Sevoflurane Versus Isoflurane on Emergence Time and Postanesthesia Care Unit Length of Stay: An Alternating Intervention Trial". Anesthesia and Analgesia. 130 (2): 360–366. doi:10.1213/ANE.0000000000004093. PMID 30882520.{{cite journal}}: CS1 maint: overridden setting (link)

[10] Sloan MH, Conard PF, Karsunky PK, Gross JB (March 1996). "Sevoflurane versus isoflurane: induction and recovery characteristics with single-breath inhaled inductions of anesthesia". Anesthesia and Analgesia. 82 (3): 528–532. doi:10.1213/00000539-199603000-00018. PMID 8623956.

[11] Smith I, Ding Y, White PF (February 1992). "Comparison of induction, maintenance, and recovery characteristics of sevoflurane-N2O and propofol-sevoflurane-N2O with propofol-isoflurane-N2O anesthesia". Anesthesia and Analgesia. 74 (2): 253–259. doi:10.1213/00000539-199202000-00015. PMID 1731547. S2CID 12345796.

[WHO23rd-12] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

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Sevoflurane

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