Father Simon Le Moyne SJ (22 October 1604 – 24 November 1665), sometimes spelled Simon Le Moine, was a French Jesuit priest who became involved with the mission to the Hurons and Iroquois in the Americas. Le Moyne had acquired sixteen years of education and experience through priesthood in France before his arrival in New France in 1638. During that same year, he headed out to his mission in Huron country. The destruction of the Huron nation by the Iroquois brought him back east to what is modern day Quebec in 1650.
He then undertook numerous missions to the Iroquois at great risk to his personal safety, and lived within Onondaga and Mohawk territory. He is most notable in Canadian history for his work as an ambassador of peace to the Iroquois. Le Moyne College in Syracuse, New York is named for him.