South by Southwest is an annual music, film and interactive conference in Austin, Texas, US.
South by Southwest may also refer to:
- "South By Southwest", a 2001 episode of the American television show V.I.P.
- "South By Southwest", a 2009 episode of the American television show NCIS season 6
- Murder, She Wrote: South By Southwest, a 1997 TV movie based on the TV show Murder, She Wrote