| Steroidal antiandrogen | |
|---|---|
| Drug class | |
 Cyproterone acetate, the most widely employed steroidal antiandrogen. | |
| Class identifiers | |
| Synonyms | Steroidal androgen receptor antagonists |
| Use | Prostate cancer; Benign prostatic hyperplasia; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Hypersexuality; Paraphilias; Male precocious puberty; Priapism |
| ATC code | G03HA |
| Biological target | Androgen receptor |
| Chemical class | Steroidal |
| Legal status | |
| In Wikidata | |
A steroidal antiandrogen (SAA) is an antiandrogen with a steroidal chemical structure.[1][2][3] They are typically antagonists of the androgen receptor (AR) and act both by blocking the effects of androgens like testosterone and dihydrotestosterone (DHT) and by suppressing gonadal androgen production.[2][3] SAAs lower concentrations of testosterone through simulation of the negative feedback inhibition of the hypothalamus.[4] SAAs are used in the treatment of androgen-dependent conditions in men and women, and are also used in veterinary medicine for the same purpose.[2] They are the converse of nonsteroidal antiandrogens (NSAAs), which are antiandrogens that are not steroids and are structurally unrelated to testosterone.[2][3]
- ^ Schröder FH, Radlmaier A (2009). "Steroidal Antiandrogens". In V. Craig Jordan, Barrington J. A. Furr (eds.). Hormone Therapy in Breast and Prostate Cancer. Humana Press. pp. 325–346. doi:10.1007/978-1-59259-152-7_15. ISBN 978-1-60761-471-5.
- ^ a b c d Singh SM, Gauthier S, Labrie F (2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. doi:10.2174/0929867003375371. PMID 10637363.
- ^ a b c Migliari R, Muscas G, Murru M, Verdacchi T, De Benedetto G, De Angelis M (1999). "Antiandrogens: a summary review of pharmacodynamic properties and tolerability in prostate cancer therapy". Arch Ital Urol Androl. 71 (5): 293–302. PMID 10673793.
- ^ Akakura K, Furuya Y, Ito H (August 1998). "[Steroidal and nonsteroidal antiandrogens: chemical structures, mechanisms of action and clinical applications]". Nihon Rinsho. Japanese Journal of Clinical Medicine. 56 (8): 2124–2128. ISSN 0047-1852. PMID 9750520.