TRPN is a member of the transient receptor potential channel family of ion channels, which is a diverse group of proteins thought to be involved in mechanoreception.[1] The TRPN gene was given the name no mechanoreceptor potential C (nompC) when it was first discovered in fruit flies,[2] hence the N in TRPN. Since its discovery in fruit flies, TRPN homologs have been discovered and characterized in worms,[3] frogs,[4] and zebrafish.[5]
- ^ Duggan, A.; García-Añoveros, J.; Corey, D. P. (2000). "Insect mechanoreception: What a long, strange TRP it's been". Current Biology. 10 (10): R384–R387. Bibcode:2000CBio...10.R384D. doi:10.1016/s0960-9822(00)00478-4. PMID 10837217.
- ^ Walker, R. G.; Willingham, A. T.; Zuker, C. S. (2000). "A Drosophila mechanosensory transduction channel". Science. 287 (5461): 2229–2234. Bibcode:2000Sci...287.2229W. CiteSeerX 10.1.1.646.2497. doi:10.1126/science.287.5461.2229. PMID 10744543.
- ^ Li, W.; Feng, Z.; Sternberg, P. W.; Shawn Xu, X. Z. (2006). "A C. Elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue". Nature. 440 (7084): 684–687. Bibcode:2006Natur.440..684L. doi:10.1038/nature04538. PMC 2865900. PMID 16572173.
- ^ Shin, J. -B.; Adams, D.; Paukert, M.; Siba, M.; Sidi, S.; Levin, M.; Gillespie, P. G.; Gründer, S. (2005). "Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells". Proceedings of the National Academy of Sciences. 102 (35): 12572–12577. Bibcode:2005PNAS..10212572S. doi:10.1073/pnas.0502403102. PMC 1194908. PMID 16116094.
- ^ Sidi, S.; Friedrich, R. W.; Nicolson, T. (2003). "NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction". Science. 301 (5629): 96–99. Bibcode:2003Sci...301...96S. doi:10.1126/science.1084370. PMID 12805553. S2CID 23882972.