| Transient receptor potential (TRP) ion channel | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Homology model of the TRPV1 ion channel tetramer (where the monomers are individually colored cyan, green, blue, and magenta respective) imbedded in a cartoon representation of a lipid bilayer. PIP2 signaling ligands are represented by space-filling models (carbon = white, oxygen = red, phosphorus = orange).[1] | |||||||||
| Identifiers | |||||||||
| Symbol | TRP | ||||||||
| Pfam | PF06011 | ||||||||
| InterPro | IPR010308 | ||||||||
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TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective.
TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.[2] TRP channels were initially discovered in the trp mutant strain of the fruit fly Drosophila [3] that displayed transient elevation of potential in response to light stimuli, and were therefore named "transient receptor potential" channels.[4] The name now refers only to a family of proteins with similar structure and function, not to the mechanism of their activation. Later, TRP channels were found in vertebrates where they are ubiquitously expressed in many cell types and tissues. There are about 28 TRP channels that share some structural similarity to each other.[5] These are grouped into two broad groups: group 1 includes TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN and TRPA. In group 2 there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin).
- ^ Brauchi S, Orta G, Mascayano C, Salazar M, Raddatz N, Urbina H, Rosenmann E, Gonzalez-Nilo F, Latorre R (June 2007). "Dissection of the components for PIP2 activation and thermosensation in TRP channels". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10246–51. Bibcode:2007PNAS..10410246B. doi:10.1073/pnas.0703420104. PMC 1891241. PMID 17548815.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Winston KR, Lutz W (March 1988). "Linear accelerator as a neurosurgical tool for stereotactic radiosurgery". Neurosurgery. 22 (3): 454–64. doi:10.1097/00006123-198803000-00002. PMID 3129667.
- ^ Cosens DJ, Manning A (October 1969). "Abnormal electroretinogram from a Drosophila mutant". Nature. 224 (5216): 285–7. Bibcode:1969Natur.224..285C. doi:10.1038/224285a0. PMID 5344615. S2CID 4200329.
- ^ Montell C, Rubin GM (April 1989). "Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction". Neuron. 2 (4): 1313–23. doi:10.1016/0896-6273(89)90069-x. PMID 2516726. S2CID 8908180.
- ^ Islam MS, ed. (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.