Antiviral medication
Tecovirimat Trade names Tpoxx Other names ST-246 AHFS /Drugs.com Monograph License data
Routes of administration By mouth , intravenous ATC code Legal status
N -{3,5-Dioxo-4-azatetracyclo[5.3.2.02,6 .08,10 ]dodec-11-en-4-yl}-4-(trifluoromethyl)benzamide
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEMBL Formula C 19 H 15 F 3 N 2 O 3 Molar mass 376.335 g·mol−1 3D model (JSmol )
FC(F)(F)c1ccc(cc1)C(=O)NN1C(=O)C2C(C3C=CC2C2CC32)C1=O
InChI=1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)
Y Key:CSKDFZIMJXRJGH-UHFFFAOYSA-N
Y
Tecovirimat , sold under the brand name Tpoxx among others,[ 6] is an antiviral medication with activity against orthopoxviruses such as smallpox and mpox .[ 4] [ 7] [ 8] In 2018 it became the first antipoxviral drug approved in the United States.[ 9] [ 10]
The drug works by blocking cellular transmission of the virus, thus preventing the disease.[ 11] It is an inhibitor of the orthopoxvirus VP37 envelope wrapping protein.[ 4]
Tecovirimat has been effective in laboratory testing; it has been shown to protect animals from mpox and rabbitpox and causes no serious side effects in humans.[ 6] Tecovirimat was first used for treatment in December 2018, after a laboratory-acquired vaccinia virus infection.[ 12]
Two million doses of tecovirimat are stockpiled in the US Strategic National Stockpile should an orthopoxvirus-based bioterror attack occur.[ 13] [ 14] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication .[ 15]
^ "Notice: Multiple Additions to the Prescription Drug List (PDL) [2022-01-24]" . Health Canada . 24 January 2022. Archived from the original on 29 May 2022. Retrieved 28 May 2022 .
^ "New Medicines Approved in 2018" . Health Canada . 15 January 2020. Archived from the original on 29 May 2022. Retrieved 28 May 2022 .
^ "Summary Basis of Decision (SBD) for Tpoxx" . Health Canada . 23 October 2014. Archived from the original on 29 May 2022. Retrieved 29 May 2022 .
^ a b c "Tpoxx- tecovirimat monohydrate capsule" . DailyMed . 2 December 2021. Archived from the original on 23 April 2022. Retrieved 23 April 2022 .
^ Cite error: The named reference Tecovirimat SIGA EPAR
was invoked but never defined (see the help page ).
^ a b McNeil Jr DG (13 July 2018). "Drug to Treat Smallpox Approved by F.D.A., a Move Against Bioterrorism" . The New York Times . Archived from the original on 28 March 2019. Retrieved 16 July 2018 .
^ Nakoune E, Olliaro P (May 2022). "Waking up to monkeypox" . BMJ . 377 : o1321. doi :10.1136/bmj.o1321 . PMID 35613732 . S2CID 249047112 .
^ Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, et al. (May 2022). "Clinical features and management of human monkeypox: a retrospective observational study in the UK" . The Lancet. Infectious Diseases . 22 (8): 1153–1162. doi :10.1016/S1473-3099(22)00228-6 . PMC 9300470 . PMID 35623380 . S2CID 249057804 .
^ "FDA approves the first drug with an indication for treatment of smallpox" . U.S. Food and Drug Administration (FDA) (Press release). 13 July 2018. Archived from the original on 23 April 2019. Retrieved 1 August 2018 .
^ "U.S. Food and Drug Administration Approves Siga Technologies' Tpoxx (tecovirimat) for the Treatment of Smallpox" . SIGA (Press release). Archived from the original on 21 September 2018. Retrieved 14 July 2018 .
^ Grosenbach DW, Honeychurch K, Rose EA, Chinsangaram J, Frimm A, Maiti B, et al. (July 2018). "Oral Tecovirimat for the Treatment of Smallpox" . The New England Journal of Medicine . 379 (1): 44–53. doi :10.1056/NEJMoa1705688 . PMC 6086581 . PMID 29972742 .
^ Whitehouse ER, Rao AK, Yu YC, Yu PA, Griffin M, Gorman S, et al. (October 2019). "Novel Treatment of a Vaccinia Virus Infection from an Occupational Needlestick - San Diego, California, 2019" (PDF) . MMWR. Morbidity and Mortality Weekly Report . 68 (42): 943–946. doi :10.15585/mmwr.mm6842a2 . PMC 6812835 . PMID 31647789 . Archived (PDF) from the original on 2 August 2022. Retrieved 2 August 2022 .
^ Damon IK, Damaso CR, McFadden G (May 2014). "Are we there yet? The smallpox research agenda using variola virus" . PLOS Pathogens . 10 (5): e1004108. doi :10.1371/journal.ppat.1004108 . PMC 4006926 . PMID 24789223 .
^ Cunningham A (13 July 2018). "FDA approves the first smallpox treatment" . Archived from the original on 12 July 2018. Retrieved 4 May 2018 .
^ New Drug Therapy Approvals 2018 (PDF) . U.S. Food and Drug Administration (FDA) (Report). January 2019. Archived from the original on 17 September 2020. Retrieved 16 September 2020 .