"There's Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics" was a lecture given by physicist Richard Feynman at the annual American Physical Society meeting at Caltech on December 29, 1959.[1] Feynman considered the possibility of direct manipulation of individual atoms as a more robust form of synthetic chemistry than those used at the time. Versions of the talk were reprinted in a few popular magazines, but it went largely unnoticed until the 1980s.