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Transcytosis

Transcytosis (also known as cytopempsis)[1] is a type of transcellular transport in which various macromolecules are transported across the interior of a cell. Macromolecules are captured in vesicles on one side of the cell, drawn across the cell, and ejected on the other side. Examples of macromolecules transported include IgA,[2] transferrin,[3] and insulin.[4] While transcytosis is most commonly observed in epithelial cells, the process is also present elsewhere. Blood capillaries are a well-known site for transcytosis,[5] though it occurs in other cells, including neurons,[6] osteoclasts[7] and M cells of the intestine.[8]

  1. ^ "cytopempsis". The Free Dictionary.
  2. ^ Perez, J. H.; Branch, W. J.; Smith, L.; Mullock, B. M.; Luzio, J. P. (1988). "Investigation of endosomal compartments involved in endocytosis and transcytosis of polymeric immunoglobulin a by subcellular fractionation of perfused isolated rat liver". The Biochemical Journal. 251 (3): 763–770. doi:10.1042/bj2510763. PMC 1149069. PMID 3415644.
  3. ^ Fishman, J. B.; Rubin, J. B.; Handrahan, J. V.; Connor, J. R.; Fine, R. E. (1987). "Receptor-mediated transcytosis of transferrin across the blood-brain barrier". Journal of Neuroscience Research. 18 (2): 299–304. doi:10.1002/jnr.490180206. PMID 3694713. S2CID 37435066.
  4. ^ Duffy, K. R.; Pardridge, W. M. (1987). "Blood-brain barrier transcytosis of insulin in developing rabbits". Brain Research. 420 (1): 32–38. doi:10.1016/0006-8993(87)90236-8. PMID 3315116. S2CID 20376106.
  5. ^ Williams, S. K.; Greener, D. A.; Solenski, N. J. (1984). "Endocytosis and exocytosis of protein in capillary endothelium". Journal of Cellular Physiology. 120 (2): 157–162. doi:10.1002/jcp.1041200208. PMID 6430919. S2CID 24779404.
  6. ^ Fabian, R. H. (1991). "Retrograde axonal transport and transcytosis of immunoglobulins: Implications for the pathogenesis of autoimmune motor neuron disease". Advances in Neurology. 56: 433–444. PMID 1853776.
  7. ^ Salo, J.; Lehenkari, P.; Mulari, M.; Metsikkö, K.; Väänänen, H. K. (1997). "Removal of osteoclast bone resorption products by transcytosis". Science. 276 (5310): 270–273. doi:10.1126/science.276.5310.270. PMID 9092479.
  8. ^ Landsverk, T. (1987). "The follicle-associated epithelium of the ileal Peyer's patch in ruminants is distinguished by its shedding of 50 nm particles". Immunology and Cell Biology. 65 (3): 251–261. doi:10.1038/icb.1987.28. PMID 3623609. S2CID 22439008.
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