Clinical data | |
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Other names | TPIE; Iodotriphenylethylene; Phenylstilbene iodide; Triphenylvinyl iodide |
Drug class | Nonsteroidal estrogen |
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PubChem CID | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C20H15I |
Molar mass | 382.244 g·mol−1 |
3D model (JSmol) | |
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Triphenyliodoethylene (TPIE), also known as iodotriphenylethylene or as phenylstilbene iodide, as well as triphenylvinyl iodide, is a synthetic nonsteroidal estrogen of the triphenylethylene group that is related to triphenylchloroethylene and triphenylbromoethylene and was never marketed.[1][2][3]
In fact the cestrogenic activity of either triphenylbromoethylene or triphenyliodoethylene (J. 3d. Robson, A. Schonberg and H. A. Fahim)(3) (Table 1) compares with that of triphenylchloroethylene. A True Oestrogen and A Pro-oestrogen.
Roughly quantitative data are reported for the antagonism between oestrogens (oestradiol, stilboestrol, doisynolic acid, allenolic acid, and triphenyliodoethylene) and progesterone, methyltestosterone, and testosterone propionate given [...]
But the synthetic oestrogens tested e.g. stilboesterol, triphenyliodoethylene, diosynolic acid and allenolic acid produce constant inhibition of the uterine motility.