 U.S. Highway 221 | ||||
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 US 221 highlighted in red | ||||
| Route information | ||||
| Maintained by GDOT | ||||
| Length | 261 mi[1] (420 km) | |||
| Existed | 1954–present | |||
| Major junctions | ||||
| South end |   US 221 / SR 55 at the Florida state line southwest of Quitman | |||
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| North end | US 221 at the SC line near Clarks Hill | |||
| Location | ||||
| Country | United States | |||
| State | Georgia | |||
| Counties | Brooks, Lowndes, Lanier, Clinch, Atkinson, Coffee, Jeff Davis, Montgomery, Treutlen, Emanuel, Johnson, Jefferson, McDuffie, Columbia | |||
| Highway system | ||||
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U.S. Route 221 (US 221) in the U.S. state of Georgia is a south–north U.S. Highway. It travels from the Florida border near the Quitman area to the South Carolina state line, north of Pollards Corner. The highway connects North Central Florida with Upstate South Carolina.
US 221 has concurrencies with Georgia State Route 76 (SR 76) from the Florida state line to Quitman, SR 333 within Quitman, SR 38 from Quitman to Valdosta, SR 7 in Valdosta, SR 31 from Valdosta to Douglas, SR 135 in Lakeland, SR 37 from Lakeland to east of Lakeland, SR 122 from Lakeland to northeast of Lakeland, SR 135 Byp. in Lakeland, SR 135 from Douglas to Uvalda, SR 32 Truck/SR 158 Truck and SR 32 in Douglas, SR 135 Conn. in Hazlehurst, SR 56 from Uvalda to Gillis Springs, SR 15 in Soperton, SR 171 from Gillis Springs to Louisville, SR 78 within the vicinity of Bartow, SR 24 within the vicinity of Louisville, SR 4 Bus. in Louisville, SR 4 and SR 17 from Louisville to Wrens, SR 88 and SR 540 in Wrens, SR 47 from Wrens to Pollards Corner, and SR 150 from Pollards Corner to the South Carolina state line.
Concurrencies of US 221 with U.S. Highways in Georgia include US 84 from Quitman to Valdosta, US 41 in Valdosta, US 129 in the vicinity of Lakeland, US 441 from south-southwest of Pearson to Douglas, part of US 23/US 341 in Hazlehurst, US 319 within the vicinity of Bartow, and US 1 from Louisville to Wrens.