U.S. Route 321 | ||||||||||||||
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 US 321 highlighted in red | ||||||||||||||
| Route information | ||||||||||||||
| Auxiliary route of US 21 | ||||||||||||||
| Length | 516.9 mi[1][2][3] (831.9 km) | |||||||||||||
| Existed | 1931–present | |||||||||||||
| Tourist routes |  Western York Scenic Byway | |||||||||||||
| Major junctions | ||||||||||||||
| South end |  US 17 in Hardeeville, SC | |||||||||||||
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| North end |    I-40 / SR 73 / SR 95 near Lenoir City, TN | |||||||||||||
| Location | ||||||||||||||
| Country | United States | |||||||||||||
| States | South Carolina, North Carolina, Tennessee | |||||||||||||
| Counties | SC: Jasper, Hampton, Allendale, Bamberg, Orangeburg, Lexington, Richland, Fairfield, Chester, York NC: Gaston, Lincoln, Catawba, Burke, Caldwell, Watauga, Avery TN: Johnson, Carter, Washington, Greene, Cocke, Sevier, Blount, Loudon | |||||||||||||
| Highway system | ||||||||||||||
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U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee, just northeast of Johnson City. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
- ^ Google (December 22, 2013). "U.S. Route 321 in South Carolina" (Map). Google Maps. Google. Retrieved December 22, 2013.
- ^ Google (December 22, 2013). "U.S. Route 321 in North Carolina" (Map). Google Maps. Google. Retrieved December 22, 2013.
- ^ Google (December 22, 2013). "U.S. Route 321 in Tennessee" (Map). Google Maps. Google. Retrieved December 22, 2013.